Overview
Cardiovascular Diseases (CVDs) are common, but in many cases can be avoided. Atherosclerosis and venous thrombosis are major manifestations. Both are influenced by environmental and genetic parameters. Testing for genetic variations and adequate prophylaxis contributes to lower CVD risks.
The system allows detection and genotyping of variants including MTHFR (c.677 and c.1298), Prothrombin (Factor II) 20210, Factor V (Leiden R506Q), FXIII (A1) V34L and SERPINE1 (PAI1) -675 (4G/5G). It is intended for use on Applied Biosystems ABI PRISM® sequencers using a five-dye fluorescent system allowing multiplex amplification and ligation in the same tube for automated SNP analysis.