Overview
The HBB gene provides instructions for making beta-globin, a subunit of hemoglobin. Hemoglobin carries oxygen in red blood cells. Mutations in HBB are associated with conditions such as beta thalassemia and sickle cell anemia.
SNP DETECTIVE HBB kit contains 2 primer pairs for amplification targets on the HBB gene. 28 region-specific probes and 56 single-base-specific fluorescence labelled DNA probes are used for detection of SNPs. The kit uses a five-dye fluorescent system allowing multiplex amplification-ligation in the same tube for automated SNP analysis. It incorporates an external control with a wild-type pattern for related mutations to support reagent performance checks and troubleshooting.